1,758 research outputs found
Mass Matrices in E6 Unification
We study a supersymmetric E6 grand unified model in which the SU(5) 5^*
components are twisted in the third generation 27. Supplementing the adjoint
Higgs field to a model analyzed previously, we calculate the mass matrices for
the up and down quarks and charged leptons. Although the number of free
parameters is less than that of observables, an overall fitting to the observed
masses and mixing angles is shown to be possible. Most notably, we find two
novel, parameter-independent relations between the lepton 2-3 mixing angle and
the quark masses and CKM mixing angles that are in good agreement with the
large lepton mixing recently observed.Comment: 33 pages, 5 figures, typos correcte
Hierarchical Mass Matrices in a Minimal SO(10) Grand Unification I
We consider a minimal SO(10) unified model with horizontal Peccei-Quinn
symmetry. The hierarchical structure of quark-lepton mass matrices is naturally
implemented by the remnants of certain irrelevant terms. Georgi-Jarlskog
relations are also realized due to the horizontal symmetry.Comment: phyzzx and tables, 15 pages, KUNS 125
Toda Lattice Solutions of Differential-Difference Equations for Dissipative Systems
In a certain class of differential-difference equations for dissipative
systems, we show that hyperbolic tangent model is the only the nonlinear system
of equations which can admit some particular solutions of the Toda lattice. We
give one parameter family of exact solutions, which include as special cases
the Toda lattice solutions as well as the Whitham's solutions in the Newell's
model. Our solutions can be used to describe temporal-spatial density patterns
observed in the optimal velocity model for traffic flow.Comment: Latex, 13 pages, 1 figur
IL-15 sustains IL-7R-independent ILC2 and ILC3 development
The signals that maintain tissue-resident innate lymphoid cells (ILC) in different microenvironments are incompletely understood. Here we show that IL-7 receptor (IL-7R) is not strictly required for the development of any ILC subset, as residual cells persist in the small intestinal lamina propria (siLP) of adult and neonatal Il7ra(−/−) mice. Il7ra(−/−) ILC2 primarily express an ST2(−) phenotype, but are not inflammatory ILC2. CCR6(+) ILC3, which express higher Bcl-2 than other ILC3, are the most abundant subset in Il7ra(−/−) siLP. All ILC subsets are functionally competent in vitro, and are sufficient to provide enhanced protection to infection with C. rodentium. IL-15 equally sustains wild-type and Il7ra(−/−) ILC survival in vitro and compensates for IL-7R deficiency, as residual ILCs are depleted in mice lacking both molecules. Collectively, these data demonstrate that siLP ILCs are not completely IL-7R dependent, but can persist partially through IL-15 signalling
Exact shock solution of a coupled system of delay differential equations: a car-following model
In this paper, we present exact shock solutions of a coupled system of delay
differential equations, which was introduced as a traffic-flow model called
{\it the car-following model}. We use the Hirota method, originally developed
in order to solve soliton equations. %While, with a periodic boundary
condition, this system has % a traveling-wave solution given by elliptic
functions. The relevant delay differential equations have been known to allow
exact solutions expressed by elliptic functions with a periodic boundary
conditions. In the present work, however, shock solutions are obtained with
open boundary, representing the stationary propagation of a traffic jam.Comment: 6 pages, 2 figure
Useful Measurement of Glucose Variability by Flash Glucose Monitoring (FGM) with the Efficacy of Sodium-Glucose Cotransporter 2 (SGLT2) Inhibitor
Diabetes has been a crucial medical and social problem worldwide. For adequate nutritional therapy, there have been discussions concerning Calorie Restriction (CR) and Low Carbohydrate Diet (LCD). We have investigated glucose variability of diabetic patients applying CR, LCD, continuous glucose monitoring (CGM) and applied FreeStyle Libre which is flash glucose monitoring (FGM). The patient is a 40-year-old female with type 2 diabetes mellitus (T2DM), who showed BMI 20.7, postprandial blood glucose 257 mg/dL. HbA1c 12.1%, Glycoalbumin 31.6% (11.6-16.4), serum C-peptide 2.0 ng/ml and unremarkable data of liver function, renal, lipids. She was provided the intervention of three stages, which are i) CR with 60% carbohydrate in Day 1-2, ii) LCD meal with 12% carbohydrate in Day 3-5; iii) LCD + Sodium-glucose cotransporter 2 (SGLT2) inhibitor (Ipragliflozin L-Proline 50mg) in Day 6-12. The glucose profile was measured by FreeStyle Libre Pro (Abbott) for 14 days. The daily profile of blood glucose was abruptly decreased on Day 6. Time percentage of satisfactory blood glucose 70-180 mg/dL (/24h) was 0%, 0%, 2%, 14%, 0%, 54%, 100% in Day 1-7, respectively. These results suppose the acute clinical efficacy of SGLT2 inhibitor, and this report would become a reference for future diabetic practice and research
Evaluating Insulin/Glucose Ratio Using Breakfast of Calorie Restriction Meal for Type 2 Diabetes Mellitus
Background: Type 2 diabetes mellitus (T2DM) has been a medical and social problem worldwide. For nutritional therapy, Low Carbohydrate Diet (LCD) and Calorie restriction (CR) have discussed for long, where authors continued clinical research.
Subjects and Methods: Subjects were 68 patients with T2DM with 62.1 years on average. Methods included i) standard CR was provided a day with 1400 kcal and 60% of carbohydrate, ii) measurement of daily profile of blood glucose, iii) insulinogenic index (IGI) (0-30 mins) exam for breakfast including 70g of carbohydrate, iv) calculation of IGI by delta and Area Under the Curves(AUC).
Results: Basal data revealed that HbA1c 7.9%, fasting glucose 163 mg/dL, average glucose in a day 210 mg/dL, M value 117 in the median. Increment of glucose/IRI was 48.0 mg/dL/8.6 μU/mL, respectively. Delta or AUC ratio of IGI was 0.14[0.08-0.26] and 3.3[2.5-5.2], respectively. There were significant correlations between M value and Delta or AUC ratio, with a higher coefficient in the latter.
Discussion and Conclusion: IGI study in Meal Tolerance Test (MTT) would be useful for pancreas function evaluation. AUC ratio method has superiority than Delta ratio with higher correlation coefficient. Current results could be the fundamental data for the related range of research, and further development will be expected
Energy Dissipation Burst on the Traffic Congestion
We introduce an energy dissipation model for traffic flow based on the
optimal velocity model (OV model). In this model, vehicles are defined as
moving under the rule of the OV model, and energy dissipation rate is defined
as the product of the velocity of a vehicle and resistant force which works to
it.Comment: 15 pages, 19 Postscript figures. Reason for replacing: This is the
submitted for
Proposal of Meal Tolerance Test (MTT) For Investigating Ability of Insulin Secretion for Small Carbohydrate Load
Authors and collaborators have continued clinical practice and research on diabetes for long, and begun Low Carbohydrate Diet (LCD) at first in Japan. We have proposed super-, standard-, petite-LCD methods with 12%, 26%, 40% of carbohydrate, and developed medical and social LCD movement by Japanese LCD promotion association (JLCDPA). For research protocol, subjects were 10 healthy young medical staff. Two tests were 75gOGTT and meal tolerance test (MTT) of breakfast of super-LCD with 300kcal and 6g of carbohydrate. Blood glucose and immunoreactive insulin (IRI) were measured at 0 min and 30 min. Results of glucose and IRI in median value (0-30min) showed as follows: i) OGTT; 89.5 mg/dL to 130.5 mg/dL, 5.1 μU/mL to 40.6 μU/mL, ii) MTT; 93.5 mg/dL to 84.5 mg/dL, 4.9μU/mL to 10.6 μU/mL (significant increase, p<0.05). The increments of IRI for GTT (carbo-75g) and MTT (carbo-6g) were analyzed. There was a significant correlation between increments of IRI in GTT and MTT (p<0.05). Blood glucose in MTT tended to decrease from 0 min to 30 min. These results suggested that insulin secretion would be sufficient and relatively excessive for 6g of carbohydrate amount
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